Structure-Based Modeling of SARS-CoV-2 Peptide/HLA-A02 Antigens.

ABSTRACT: SARS-CoV-2-specific CD4 and CD8 T cells have been shown to be present in individuals with acute, mild, and asymptomatic Coronavirus disease (COVID-19). Toward the development of diagnostic and therapeutic tools to fight COVID-19, it is important to predict and characterize T cell epitopes expressed by SARS-CoV-2. Here, we use RosettaMHC, a comparative modeling approach which leverages existing structures of peptide/MHC complexes available in the Protein Data Bank, to derive accurate 3D models for putative SARS-CoV-2 CD8 epitopes. We outline an application of our method to model 8-10 residue epitopic peptides predicted to bind to the common allele HLA-A^*02:01, and we make our models publicly available through an online database (https://rosettamhc.chemistry.ucsc.edu). We further

SUBMITTER: Nerli S 

PROVIDER: S-EPMC8757863 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature