Case-control study of adverse childhood experiences and multiple sclerosis risk and clinical outcomes.

ABSTRACT:

Background

Adverse childhood experiences (ACEs) are linked to numerous health conditions but understudied in multiple sclerosis (MS). This study's objective was to test for the association between ACEs and MS risk and several clinical outcomes.

Methods

We used a sample of adult, non-Hispanic MS cases (n = 1422) and controls (n = 1185) from Northern California. Eighteen ACEs were assessed including parent divorce, parent death, and abuse. Outcomes included MS risk, age of MS onset, Multiple Sclerosis Severity Scale score, and use of a walking aid. Logistic and linear regression estimated odds ratios (ORs) (and beta coefficients) and 95% confidence intervals (CIs) for ACEs operationalized as any/none, counts, individual events, and latent factors/patterns.

Results

Overa

SUBMITTER: Horton MK 

PROVIDER: S-EPMC8757911 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature