Diagnostic performance of oral swabs for non-sputum based TB diagnosis in a TB/HIV endemic setting.

ABSTRACT:

Objective

We evaluated diagnostic performance of oral swab analysis (OSA) for tuberculosis (TB) in a high HIV/TB burden setting in Kenya.

Methods

In this cross-sectional study, buccal swabs and sputum were collected from 100 participants with suspected TB in outpatient clinics in Kenya at enrollment and subsequent morning visits. Buccal swabs underwent IS6110-targeted qPCR analysis. Sputum was evaluated by Xpert MTB/RIF (Xpert) and culture. Diagnostic performance of OSA for TB diagnosis was evaluated relative to a combined reference of sputum Xpert and culture.

Results

Among 100 participants, 54% were living with HIV (PLHIV). Twenty percent (20/100) of participants had confirmed TB (19/20 [95%] culture-positive, 17/20 [85%] Xpert-positive). Overall buccal swab sensiti

SUBMITTER: LaCourse SM 

PROVIDER: S-EPMC8758000 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature