MiR-27a-3p regulates expression of intercellular junctions at the brain endothelium and controls the endothelial barrier permeability.

ABSTRACT:

Background

The brain endothelial barrier permeability is governed by tight and adherens junction protein complexes that restrict paracellular permeability at the blood-brain barrier (BBB). Dysfunction of the inter-endothelial junctions has been implicated in neurological disorders such as multiple sclerosis, stroke and Alzheimer's disease. The molecular mechanisms underlying junctional dysfunction during BBB impairment remain elusive. MicroRNAs (miRNAs) have emerged as versatile regulators of the BBB function under physiological and pathological conditions, and altered levels of BBB-associated microRNAs were demonstrated in a number of brain pathologies including neurodegeneration and neuroinflammatory diseases. Among the altered micro-RNAs, miR-27a-3p was found to be downregulated

SUBMITTER: Harati R 

PROVIDER: S-EPMC8758013 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature