Ontology highlight
ABSTRACT:
SUBMITTER: Loreto A
PROVIDER: S-EPMC8758145 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Loreto Andrea A Angeletti Carlo C Gu Weixi W Osborne Andrew A Nieuwenhuis Bart B Gilley Jonathan J Merlini Elisa E Arthur-Farraj Peter P Amici Adolfo A Luo Zhenyao Z Hartley-Tassell Lauren L Ve Thomas T Desrochers Laura M LM Wang Qi Q Kobe Bostjan B Orsomando Giuseppe G Coleman Michael P MP
eLife 20211206
Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the NAD-consuming enzyme SARM1. Here, we report a novel activator of SARM1, a metabolite of the pesticide and neurotoxin vacor. Removal of SARM1 completely rescues mouse neurons from vacor-induced neuron and axon death in vitro and in vivo. We present the crystal structure of the <i>Drosophila</i> SARM1 regulatory domain complexed with this a ...[more]