Innate-like NKp30⁺CD8⁺ T cells armed with TCR/CAR target tumor heterogeneity.

ABSTRACT: Intratumoral heterogeneity is frequently associated with tumor immune escape, with MHC-class I and antigen expression loss rendering tumor cells invisible to T cell killing, representing a major challenge for the design of successful adoptive transfer protocols for cancer immunotherapy. While CD8⁺ T cell recognition of tumor cells is based on the detection of MHC-peptide complexes via specific T cell receptors (TCRs), Natural Killer (NK) cells detect tumor-associated NK ligands by an array of NK receptors. We have recently identified a population of innate-like CD8⁺ T cells marked by the expression of NKp30, a potent natural cytotoxicity activating NK receptor, whose tumor ligand, B7H6, is frequently upregulated on several cancer types. Here, we harnessed the dual-rec

SUBMITTER: Correia MP 

PROVIDER: S-EPMC8758178 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature