The Diagnostic Value of ¹⁸F-FDG PET/CT Bone Marrow Uptake Pattern in Detecting Bone Marrow Involvement in Pediatric Neuroblastoma Patients.

ABSTRACT:

Objectives

To explore the diagnostic value of ¹⁸F-FDG PET/CT bone marrow uptake pattern (BMUP) in detecting bone marrow involvement (BMI) in pediatric neuroblastoma (NB) patients.

Methods

Ninety-eight NB patients were enrolled in BMI analysis. Four patterns of bone marrow uptake were categorized based on pretreatment ^cF-FDG PET/CT images. Some crucial inspection indexes and ¹⁸F-FDG PET/CT metabolic parameters were analyzed. The BMUP was divided into BMUP1, BMUP2, BMUP3, and BMUP4. Paired-like homeobox 2b (PHOX2B) of bone marrow and blood, bone marrow biopsy (BMB) result, and ¹⁸F-FDG PET/CT were compared to detect BMI. All patients were followed up for at least six months.

Results

BMUP had excellent consistency among differen

SUBMITTER: Liu J 

PROVIDER: S-EPMC8758298 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature