Activation of trace amine-associated receptor 1 selectively attenuates the reinforcing effects of morphine.

ABSTRACT:

Background and purpose

Trace amine-associated TA₁ receptors play critical roles in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TA₁ receptors modulates addiction-like behaviours associated with psychostimulants. However, little is known about whether TA₁ receptor modulation would regulate the behavioural effects of opioids.

Experimental approach

Effects of the selective TA₁ receptor partial agonist RO5263397 on the addiction-related and antinociceptive effects of morphine were systematically assessed in male rats and mice.

Key results

RO5263397 attenuated the expression of morphine-induced behavioural sensitization in wildtype but not TA₁

SUBMITTER: Liu J 

PROVIDER: S-EPMC8758336 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature