Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.

ABSTRACT: Cell dispersion from a confined area is fundamental in a number of biological processes, including cancer metastasis. To date, a quantitative understanding of the interplay of single-cell motility, cell proliferation, and intercellular contacts remains elusive. In particular, the role of E- and N-cadherin junctions, central components of intercellular contacts, is still controversial. Combining theoretical modeling with in vitro observations, we investigate the collective spreading behavior of colonies of human cancer cells (T24). The spreading of these colonies is driven by stochastic single-cell migration with frequent transient cell-cell contacts. We find that inhibition of E- and N-cadherin junctions decreases colony spreading and average spreading velocities, without affecting the str

SUBMITTER: Zisis T 

PROVIDER: S-EPMC8758422 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature