APOEε4 potentiates the relationship between amyloid-β and tau pathologies.

ABSTRACT: APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and is associated with cerebral amyloid-β. However, the association between APOEε4 and tau pathology, the other major proteinopathy of Alzheimer's disease, has been controversial. Here, we sought to determine whether the relationship between APOEε4 and tau pathology is determined by local interactions with amyloid-β. We examined three independent samples of cognitively unimpaired, mild cognitive impairment and Alzheimer's disease subjects: (1) 211 participants who underwent tau-PET with [¹⁸F]MK6240 and amyloid-PET with [¹⁸F]AZD4694, (2) 264 individuals who underwent tau-PET with [¹⁸F]Flortaucipir and amyloid-PET with [¹⁸F]Florbetapir and (3) 487 individuals w

SUBMITTER: Therriault J 

PROVIDER: S-EPMC8758492 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature