Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterials.

ABSTRACT: The development of effective assay techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently received research attention due to its rapid worldwide spread and considerable risk to human health. The receptor-binding domain (RBD) of the spike (S) protein in SARS-CoV-2, a key component for viral entry that has a unique sequence compared to other structural proteins, has been considered an important diagnostic target. In this respect, low-frequency vibrational modes have the advantage of providing information about compositional and structural dependencies at the peptide level. In this study, the sensitive and selective detection of peptides derived from the RBD in SARS-CoV-2 and SARS-CoV was investigated using metamaterial-based sensing chips with a terahertz ti

SUBMITTER: Lee SH 

PROVIDER: S-EPMC8758572 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature