The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ.

ABSTRACT: Microenvironmental and molecular factors mediating the progression of Breast Ductal Carcinoma In Situ (DCIS) are not well understood, impeding the development of prevention strategies and the safe testing of treatment de-escalation. We addressed methodological barriers and characterized the mutational, transcriptional, histological, and microenvironmental landscape across 85 multiple microdissected regions from 39 cases. Most somatic alterations, including whole-genome duplications, were clonal, but genetic divergence increased with physical distance. Phenotypic and subtype heterogeneity was frequently associated with underlying genetic heterogeneity and regions with low-risk features preceded those with high-risk features according to the inferred phylogeny. B- and T-lymphocytes spatial a

SUBMITTER: Nachmanson D 

PROVIDER: S-EPMC8758681 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature