Analysis of Fomepizole Elimination in Methanol- and Ethylene Glycol-Poisoned Patients.

ABSTRACT:

Introduction

Fomepizole is an anti-metabolite therapy that is used to diminish the toxicity from methanol or ethylene glycol. Although its elimination kinetics have been well described in healthy human subjects, the elimination in poisoned patients have only been described in a few isolated cases. This study was designed to relate the elimination of fomepizole in a series of poisoned patients to that in healthy humans.

Methods

Plasma samples from 26 patients in the clinical trials of the use of fomepizole for methanol and ethylene glycol poisoning were analyzed for fomepizole concentrations. The elimination of fomepizole was assessed after individual doses, both during and without intermittent hemodialysis.

Results

In methanol- and ethylene glycol-poisoned patients, f

SUBMITTER: McMartin K 

PROVIDER: S-EPMC8758829 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature