Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice.

ABSTRACT: Chronic gut inflammation such as inflammatory bowel disease is believed to be associated with neurodegenerative diseases in humans. However, the direct evidence for and the underlying mechanism of this brain-gut interaction remain elusive. In this study, manganese-enhanced magnetic resonance imaging was used to assess functional brain activity from awake and freely moving mice with chronic colitis. Manganese ion uptake (indicative of Ca²⁺ influx into neuronal cells) and accumulation were reduced in the hippocampus of chronic colitis mice compared with control mice. Long-term memory declined and neuroinflammatory signals, including IL-1β production and activation of caspase-1, caspase-11, and gasdermin, were induced. High-mobility group box 1 (HMGB1) levels were elevated both in

SUBMITTER: Mitchell J 

PROVIDER: S-EPMC8759038 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature