Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas.

ABSTRACT: Membrane transport proteins fulfill important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane transport, have been successfully developed. However, to confer stimuli-responsiveness on them poses a fundamental challenge. Here we demonstrate photocontrol of transmembrane transport and electric potential using bis(thio)ureas derived from stiff-stilbene. UV-vis and ¹H NMR spectroscopy are used to monitor E-Z photoisomerization of these bis(thio)ureas and ¹H NMR titrations reveal stronger binding of chloride to the (Z)-form than to the (E)-form. Additional insight into the binding properties is provided by single

SUBMITTER: Wezenberg SJ 

PROVIDER: S-EPMC8759083 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature