Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation.

ABSTRACT: Extracellular vesicles (EV) have been implicated in diverse biological processes, including intracellular communication, transport of nucleic acids, and regulation of vascular function. Levels of EVs are elevated in cancer, and studies suggest that EV may stimulate thrombosis in patients with cancer through expression of tissue factor. However, limited data also implicate EV in the activation of the contact pathway of coagulation through activation of factor XII (FXII) to FXIIa. To better define the ability of EV to initiate contact activation, we compared the ability of EV derived from different cancer cell lines to activate FXII. EV from all cell lines activated FXII, with those derived from pancreatic and lung cancer cell lines demonstrating the most potent activity. Concordant with the

SUBMITTER: Shim YJ 

PROVIDER: S-EPMC8759128 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature