Genetic architecture of four smoking behaviors using partitioned SNP heritability.

ABSTRACT:

Background and aims

Although genome-wide association studies have identified many loci that influence smoking behaviors, much of the genetic variance remains unexplained. We characterized the genetic architecture of four smoking behaviors using single nucleotide polymorphism (SNP) heritability (h²_SNP ). This is an estimate of narrow-sense heritability specifically estimating the proportion of phenotypic variation due to causal variants (CVs) tagged by SNPs.

Design

Partitioned h²_SNP analysis of smoking behavior traits.

Setting

UK Biobank.

Participants

UK Biobank participants of European ancestry. The number of participants varied depending on the trait, from 54 792 to 323 068.

Measurements

Smoking initiation, ag

SUBMITTER: Evans LM 

PROVIDER: S-EPMC8759147 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature