Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder.

ABSTRACT:

Background

Substance use occurs at a high rate in persons with a psychiatric disorder. Genetically informative studies have the potential to elucidate the etiology of these phenomena. Recent developments in genome-wide association studies (GWAS) allow new avenues of investigation.

Method

Using results of GWAS meta-analyses, we performed a factor analysis of the genetic correlation structure, a genome-wide search of shared loci, and causally informative tests for six substance use phenotypes (four smoking, one alcohol, and one cannabis use) and five psychiatric disorders (ADHD, anorexia, depression, bipolar disorder, and schizophrenia).

Results

Two correlated externalizing and internalizing/psychosis factor were found, although model fit was beneath conventional standa

SUBMITTER: Jang SK 

PROVIDER: S-EPMC8759148 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature