Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis.

ABSTRACT:

Background

Toxoplasma gondii (T. gondii) is a highly successful parasite being able to cross all biological barriers of the body, finally reaching the central nervous system (CNS). Previous studies have highlighted the critical involvement of the blood-brain barrier (BBB) during T. gondii invasion and development of subsequent neuroinflammation. Still, the potential contribution of the choroid plexus (CP), the main structure forming the blood-cerebrospinal fluid (CSF) barrier (BCSFB) have not been addressed.

Methods

To investigate T. gondii invasion at the onset of neuroinflammation, the CP and brain microvessels (BMV) were isolated and analyzed for parasite burden. Additionally, immuno-stained brain sections and three-dimensional whole mount preparations were evaluated for

SUBMITTER: Figueiredo CA 

PROVIDER: S-EPMC8759173 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature