Human plasma pregnancy-associated miRNAs and their temporal variation within the first trimester of pregnancy.

ABSTRACT:

Background

During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs). These small non-coding RNAs regulate numerous biological functions, mostly through post-transcriptional repression of gene expression. miRNAs are also secreted in circulation by numerous organs, such as the placenta. However, the complete plasmatic microtranscriptome of pregnant women has still not been fully described, although some miRNA clusters from the chromosome 14 (C14MC) and the chromosome 19 (C19MC and miR-371-3 cluster) have been proposed as being specific to pregnancy. Our aims were thus to describe the plasma microtranscriptome during the first trimes

SUBMITTER: Legare C 

PROVIDER: S-EPMC8759232 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature