Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions.

ABSTRACT:

Background

Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and plays a major role in shaping the adaptive immune response. However, this phagocyte is a target and host for many pathogens. Understanding the molecular basis of interactions between macrophages and pathogens is therefore crucial for the development of effective strategies to combat important infectious diseases.

Results

We explored how porcine pluripotent stem cells (PSCs) can provide a limitless in vitro supply of genetically and experimentally tractable macrophages. Porcine PSC-derived macrophages (PSCdMs) exhibited molecular and func

SUBMITTER: Meek S 

PROVIDER: S-EPMC8759257 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature