Arterial health during early childhood following abnormal fetal growth.

ABSTRACT:

Background

Abnormal fetal growth is associated with increased cardiovascular risk in adulthood. We investigated the effect of fetal programming on arterial health and morphology during early childhood.

Methods

We examined 90 children (median age 5.81 years, interquartile range: 5.67; 5.95), born small for gestational age with fetal growth restriction, large or appropriate for gestational age (SGA, N = 23, LGA, N = 19, AGA N = 48). We measured body composition, anthropometrics, blood pressure, pulse wave velocity (PWV), lipids, glucose and inflammatory markers, and assessed carotid, brachial, radial and femoral arterial morphology and stiffness using very-high resolution ultrasound (46-71 MHz).

Results

LGA showed increased anthropometry, lean body mass and body mass in

SUBMITTER: Olander RFW 

PROVIDER: S-EPMC8759262 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature