Association between Intermittent Hypoxemia and Severe Bronchopulmonary Dysplasia in Preterm Infants.

ABSTRACT: Rationale: Bronchopulmonary dysplasia increases the risk of disability in extremely preterm infants. Although the pathophysiology remains uncertain, prior exposure to intermittent hypoxemia may play a role in this relationship. Objectives: To determine the association between prolonged episodes of intermittent hypoxemia and severe bronchopulmonary dysplasia. Methods: A post hoc analysis of extremely preterm infants in the Canadian Oxygen Trial who survived to 36 weeks' postmenstrual age was performed. Oxygen saturations <80% for ⩾1 minute and the proportion of time per day with hypoxemia were quantified using continuous pulse oximetry data that had been sampled every 10 seconds from within 24 hours of birth until 36 weeks' postmenstrual age. The study outcome wa

SUBMITTER: Jensen EA 

PROVIDER: S-EPMC8759313 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature