CTRP3 as a novel biomarker in the plasma of Saudi children with autism.

ABSTRACT:

Background

C1q/tumor necrosis factor-related protein-3 (CTRP3) has diverse functions: anti-inflammation, metabolic regulation, and protection against endothelial dysfunction.

Methods

The plasma level of CTRP3 in autistic patients (n = 32) was compared to that in controls (n = 37) using ELISA.

Results

CTRP3 was higher (24.7% with P < 0.05) in autistic patients than in controls. No association was observed between CTRP3 and the severity of the disorder using the Childhood Autism Rating Scale (CARS). A positive correlation between CARs and the age of patients was reported. Receiver operating characteristic (ROC) analysis demonstrated a low area under the curve (AUC) for all patients (0.636). Low AUCs were also found in the case of severe patients (0.

SUBMITTER: Alhakbany M 

PROVIDER: S-EPMC8759357 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature