SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior.

ABSTRACT:

Objective

SNAP-25 is one of the key proteins involved in formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes that are at the core of hormonal secretion and synaptic transmission. Altered expression or function of SNAP-25 can contribute to the development of neuropsychiatric and metabolic disease. A dominant negative (DN) I67T missense mutation in the b-isoform of SNAP-25 (DN-SNAP25mut) mice leads to abnormal interactions within the SNARE complex and impaired exocytotic vesicle recycling, yet the significance of this mutation to any association between the central nervous system and metabolic homeostasis is unknown.

Methods

Here we explored aspects of metabolism, steroid hormone production and neurobehavior of DN-SNAP25mut mice

SUBMITTER: Hao X 

PROVIDER: S-EPMC8759409 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature