Dendritic cell maturation in HCV infection: altered regulation of MHC class I antigen processing-presenting machinery.

ABSTRACT:

Background & aims

Modulation of dendritic cell (DC) function has been theorized as one of the mechanisms used by hepatitis C virus (HCV) to evade the host immune response and cause persistent infection.

Methods

We used a range of cell and molecular biology techniques to study DC subsets from uninfected and HCV-infected individuals.

Results

We found that patients with persistent HCV infection have lower numbers of circulating myeloid DC and plasmacytoid DC than healthy controls or patients who spontaneously recovered from HCV infection. Nonetheless, DC from patients with persistent HCV infection display normal phagocytic activity, typical expression of the class I and II HLA and co-stimulatory molecules, and conventional cytokine production when stimulated to mature in

SUBMITTER: Leone P 

PROVIDER: S-EPMC8759579 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature