Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity.

ABSTRACT: Phenotypes can change during exposure to different environments through the regulation of signaling pathways that operate in integrated networks. How signaling networks produce different phenotypes in different settings is not fully understood. Here, Gene by Environment Interactions (GEIs) were used to explore the regulatory network that controls filamentous/invasive growth in the yeast Saccharomyces cerevisiae. GEI analysis revealed that the regulation of invasive growth is decentralized and varies extensively across environments. Different regulatory pathways were critical or dispensable depending on the environment, microenvironment, or time point tested, and the pathway that made the strongest contribution changed depending on the environment. Some regulators even showed conditional ro

SUBMITTER: Vandermeulen MD 

PROVIDER: S-EPMC8759647 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature