Effects of replacement therapies with clotting factors in patients with hemophilia: A systematic review and meta-analysis.

ABSTRACT:

Background

Different prophylactic and episodic clotting factor treatments are used in the management of hemophilia. A summarize of the evidence is needed inform decision-making.

Objective

To compare the effects of factor replacement therapies in patients with hemophilia.

Methods

We performed a systematic search in PubMed, Central Cochrane Library, and Scopus. We included randomized controlled trials (RCTs) published up to December 2020, which compared different factor replacement therapies in patients with hemophilia. Random-effects meta-analyses were performed whenever possible. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The study protocol was registered in PROSPERO (CRD

SUBMITTER: Delgado-Flores CJ 

PROVIDER: S-EPMC8759703 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature