Antithrombotic therapy for secondary prevention of unprovoked venous thromboembolism: a systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Extended antithrombotic treatment is recommended for secondary prevention of unprovoked venous thromboembolism (VTE), however, there is no consensus on which antithrombotic strategy is preferable.

Aim

To compare the efficacy and safety of different antithrombotic strategies for secondary prevention unprovoked VTE.

Methods

Cochrane Central Register of Controlled Trials, Embase, and MEDLINE were systematically searched from inception to 22 July 2020 for randomized controlled trials (RCTs) that compared the efficacy and/or safety of extended antithrombotic strategies including aspirin, warfarin and direct oral anticoagulants (DOACs) for secondary prevention of unprovoked VTE. The primary outcome was risk of major bleeding and the secondary outcomes were risks

SUBMITTER: Li D 

PROVIDER: S-EPMC8759723 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature