Quantifying structural relationships of metal-binding sites suggests origins of biological electron transfer.

ABSTRACT: Biological redox reactions drive planetary biogeochemical cycles. Using a novel, structure-guided sequence analysis of proteins, we explored the patterns of evolution of enzymes responsible for these reactions. Our analysis reveals that the folds that bind transition metal–containing ligands have similar structural geometry and amino acid sequences across the full diversity of proteins. Similarity across folds reflects the availability of key transition metals over geological time and strongly suggests that transition metal–ligand binding had a small number of common peptide origins. We observe that structures central to our similarity network come primarily from oxidoreductases, suggesting that ancestral peptides may have also facilitated electron transfer reactions. Last, our results rev

SUBMITTER: Bromberg Y 

PROVIDER: S-EPMC8759750 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature