SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies.

ABSTRACT: Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median age of 87 years and 56 years, respectively), who had survived COVID-19 outbreaks with only mild or asymptomatic infection. The cohort was selected because of its high proportion of individuals who had lost neutralizing antibodies (nAbs), thus allowing us to specifically investigate the reserve immunity from SARS-CoV-2-specific MBCs in this setting. Class-switched spike and receptor-binding domain (RBD) tetramer-binding MBCs persisted 5 months after mild or asymptomatic SARS-CoV-2 infection, irrespective of age. The majority of spike- and RBD-spe

SUBMITTER: Jeffery-Smith A 

PROVIDER: S-EPMC8759779 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature