Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions.

ABSTRACT: Vast numbers of differentially expressed genes and perturbed networks have been identified in Alzheimer's disease (AD), however, neither disease nor brain region specificity of these transcriptome alterations has been explored. Using RNA-Seq data from 231 temporal cortex and 224 cerebellum samples from patients with AD and progressive supranuclear palsy (PSP), a tauopathy, we identified a striking correlation in the directionality and magnitude of gene expression changes between these 2 neurodegenerative proteinopathies. Further, the transcriptomic changes in AD and PSP brains ware highly conserved between the temporal and cerebellar cortices, indicating that highly similar transcriptional changes occur in pathologically affected and grossly less affected, albeit functionally connected, ar

SUBMITTER: Wang X 

PROVIDER: S-EPMC8759790 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature