Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.

ABSTRACT: Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and sma

SUBMITTER: McWhinney SR 

PROVIDER: S-EPMC8760047 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature