Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse.

ABSTRACT: The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of the ventral tegmental area, which projects to limbic structures controlling complex behaviors. OTX2 is also produced in choroid plexus epithelium, from which it is secreted into cerebrospinal fluid and transferred to limbic structure parvalbumin interneurons. Previously, adult male mice subjected to early-life stress were found susceptible to anxiety-like behaviors, with accompanying OTX2 expression changes in ventral tegmental area or choroid plexus. Here, we investigated the consequences of reduced OTX2 levels in Otx2 heterozygote mice, as well as in Otx2^+/AA and scFvOtx2^tg/0 mouse models for decreasing OTX2 transfer from choroid plexus to parvalbumin interneurons. Both male and f

SUBMITTER: Vincent C 

PROVIDER: S-EPMC8760049 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature