Ontology highlight
ABSTRACT:
SUBMITTER: Wang XL
PROVIDER: S-EPMC8760060 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Wang Xiao-Lan XL Kooijman Sander S Gao Yuanqing Y Tzeplaeff Laura L Cosquer Brigitte B Milanova Irina I Wolff Samantha E C SEC Korpel Nikita N Champy Marie-France MF Petit-Demoulière Benoit B Goncalves Da Cruz Isabelle I Sorg-Guss Tania T Rensen Patrick C N PCN Cassel Jean-Christophe JC Kalsbeek Andries A Boutillier Anne-Laurence AL Yi Chun-Xia CX
Molecular psychiatry 20210528 11
Microglia play a critical role in maintaining neural function. While microglial activity follows a circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in stimulated conditions such as in the control of systemic energy homeostasis or memory formation. In this study, we found that microglia-specific knock-down of the core clock gene, Bmal1, resulted in increased microglial phagocytosis in mice subjected to high-fat diet (HFD)-induced metabolic stress an ...[more]