Could maternal thyroid function during pregnancy affect daughters' age at menarche through child growth? A mediation analysis.

ABSTRACT: Early menarche is associated with adverse health outcomes during adolescence as well as breast and other reproductive cancers later in adulthood. However, the causes of early menarche and the pathways through which they operate are not fully understood. Though maternal thyroid function during pregnancy affects child growth, and rapid childhood growth is associated with a decreased age at menarche, the relationship between prenatal maternal thyroid function and daughters' age at menarche has not been examined. We conducted a mediation analysis in a historical cohort of 260 mother-child pairs to estimate the total and indirect effects of maternal prenatal thyroid function on daughters' age at menarche. No association was observed between thyroid stimulating hormone (TSH) or anti-thyroid pero

SUBMITTER: Siegel EL 

PROVIDER: S-EPMC8760156 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature