Incremental Impact of [⁶⁸ Ga]Ga-PSMA-11 PET/CT in Primary N and M Staging of Prostate Cancer Prior to Curative-Intent Surgery: a Prospective Clinical Trial in Comparison with mpMRI.

ABSTRACT:

Purpose

The main objective of this prospective study was to assess the value of gallium-68 prostate-specific membrane antigen ([⁶⁸ Ga]Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) in primary N and M staging of intermediate- and high-risk prostate cancer (PCa) patients before planned curative-intent radical prostatectomy (RPE) and extended pelvic lymph node dissection (ePLND). The second objective was to compare the [⁶⁸ Ga]Ga-PSMA-11 PET/CT findings with standard of care pelvic multi-parametric magnetic resonance imaging (mpMRI) in the detection of locoregional lymph node metastases and intraprostatic prostate cancer.

Procedures

A total of 81 patients (mean age: 64.5 years, baseline mean trigger PSA (tPSA) 15.4 ng/ml, ± 15.9) with

SUBMITTER: Szigeti F 

PROVIDER: S-EPMC8760214 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature