Examining the Feasibility of Quantifying Receptor Availability Using Cross-Modality Paired-Agent Imaging.

ABSTRACT:

Purpose

The ability to noninvasively quantify receptor availability (RA) in solid tumors is an aspirational goal of molecular imaging, often challenged by the influence of non-specific accumulation of the contrast agent. Paired-agent imaging (PAI) techniques aim to compensate for this effect by imaging the kinetics of a targeted agent and an untargeted isotype, often simultaneously, and comparing the kinetics of the two agents to estimate RA. This is usually accomplished using two spectrally distinct fluorescent agents, limiting the technique to superficial tissues and/or preclinical applications. Applying the approach in humans using conventional imaging modalities is generally infeasible since most modalities are unable to routinely image multiple agents simultaneously. We examin

SUBMITTER: Meng B 

PROVIDER: S-EPMC8760219 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature