ALKBH5-mediated N⁶-methyladenosine modification of TRERNA1 promotes DLBCL proliferation via p21 downregulation.

ABSTRACT: Long noncoding RNAs (lncRNAs) have crucial functions in the tumorigenesis and metastasis of cancers. N⁶-methyladenosine (m⁶A) modification of RNA is an important epigenetic regulatory mechanism in various malignancies. Nevertheless, the mechanism of m⁶A-modified lncRNA in diffuse large B cell lymphoma (DLBCL) has remained poorly defined. In the present study, we showed that lncRNA TRERNA1 was associated with the poor prognosis of DLBCL patients. TRERNA1 with internal m⁶A modification was highly correlated with the demethylase ALKBH5 expression. We further demonstrated that TRERNA1 was a potential downstream target of ALKBH5-mediated m⁶A modification by m⁶A-RNA sequencing and m⁶A-RIP assays. Decreased m⁶

SUBMITTER: Song W 

PROVIDER: S-EPMC8760254 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature