Preimmunization correlates of protection shared across malaria vaccine trials in adults.

ABSTRACT: Identifying preimmunization biological characteristics that promote an effective vaccine response offers opportunities for illuminating the critical immunological mechanisms that confer vaccine-induced protection, for developing adjuvant strategies, and for tailoring vaccination regimens to individuals or groups. In the context of malaria vaccine research, studying preimmunization correlates of protection can help address the need for a widely effective malaria vaccine, which remains elusive. In this study, common preimmunization correlates of protection were identified using transcriptomic data from four independent, heterogeneous malaria vaccine trials in adults. Systems-based analyses showed that a moderately elevated inflammatory state prior to immunization was associated with protecti

SUBMITTER: Neal ML 

PROVIDER: S-EPMC8760258 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature