Cardiovascular diseases among diffuse large B-cell lymphoma long-term survivors in Asia: a multistate model study.

ABSTRACT:

Background

We modeled the clinical course of a cohort of diffuse large B-cell lymphoma (DLBCL) patients with no prior cardiovascular diseases (CVDs) using a multistate modeling framework.

Patients and methods

Data on 2600 patients with DLBCL diagnosed between 2000 and 2018 and had received chemotherapy with or without radiotherapy were obtained from a population-wide electronic health database of Hong Kong. We used the Markov illness-death model to quantify the impact of doxorubicin and various risk factors (therapeutic exposure, demographic, comorbidities, cardiovascular risk factors, and lifestyle factors which included smoking) on the clinical course of DLBCL (transitions into incident CVD, lymphoma death, and other causes of death).

Results

A total of 613 (23.6%)

SUBMITTER: Lee SF 

PROVIDER: S-EPMC8760397 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature