Leptomeningeal enhancement in multiple sclerosis and other neurological diseases: A systematic review and Meta-Analysis.

ABSTRACT:

Background

The lack of systematic evidence on leptomeningeal enhancement (LME) on MRI in neurological diseases, including multiple sclerosis (MS), hampers its interpretation in clinical routine and research settings.

Purpose

To perform a systematic review and meta-analysis of MRI LME in MS and other neurological diseases.

Materials and methods

In a comprehensive literature search in Medline, Scopus, and Embase, out of 2292 publications, 459 records assessing LME in neurological diseases were eligible for qualitative synthesis. Of these, 135 were included in a random-effects model meta-analysis with subgroup analyses for MS.

Results

Of eligible publications, 161 investigated LME in neoplastic neurological (n = 2392), 91 in neuroinfectious (n = 1890), and 75 in p

SUBMITTER: Ineichen BV 

PROVIDER: S-EPMC8760523 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature