Dataset Information
Assessment of androgen receptor, IGF-IR and insulin receptor expression in male patients with severe peripheral artery disease.
Ontology highlight
ABSTRACT: Background
Peripheral artery disease (PAD) of the lower limbs is a common condition that can affect quality of life. Androgen receptor (AR) can exert sex-specific effects on metabolic system, endothelial function and vascular tone. IGF-I receptor (IGF-IR) and insulin receptor (IR) may also be involved in the aforementioned functions. The aim of this study was to evaluate AR, IGF-IR and IR expression in the arterial vessel walls of PAD patients.Results
This is a cross-sectional study examining 30 males with PAD undergoing open surgery procedures. Mean age was 75.9 ± 8.8y. All patients belonged to Rutherford stage 4-6. Median expression levels of IR, IGF-IR and AR significantly decreased from stage 4-6 (p < 0.05).Significance
The study evidenced a progressive decrease of IR, IGF-IR and AR expression as the severity of disease increased. Altered levels of IR, IGF-IR and AR following PAD may be useful for the clinical evaluation of these patients.
SUBMITTER: Andreucci M
PROVIDER: S-EPMC8760540 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Assessment of androgen receptor, IGF-IR and insulin receptor expression in male patients with severe peripheral artery disease.
Heliyon 20220112 1
<h4>Background</h4>Peripheral artery disease (PAD) of the lower limbs is a common condition that can affect quality of life. Androgen receptor (AR) can exert sex-specific effects on metabolic system, endothelial function and vascular tone. IGF-I receptor (IGF-IR) and insulin receptor (IR) may also be involved in the aforementioned functions. The aim of this study was to evaluate AR, IGF-IR and IR expression in the arterial vessel walls of PAD patients.<h4>Results</h4>This is a cross-sectional st ...[more]