Understanding bias when estimating life expectancy from age at death: a simulation approach applied to Morquio syndrome A.

ABSTRACT:

Objective

Life expectancy can be estimated accurately from a cohort of individuals born in the same year and followed from birth to death. However, due to the resource-consuming nature of following a cohort prospectively, life expectancy is often assessed based upon retrospective death record reviews. This conventional approach may lead to potentially biased estimates, in particular when estimating life expectancy of rare diseases such as Morquio syndrome A. We investigated the accuracy of life expectancy estimation using death records by simulating the survival of individuals with Morquio syndrome A under four different scenarios.

Results

When life expectancy was constant during the entire period, using death data did not result in a biased estimate. However, when life expe

SUBMITTER: Yin X 

PROVIDER: S-EPMC8760562 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature