Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

ABSTRACT:

Background

Lung carcinoma is a common geriatric disease. The development of genotype-targeted therapies greatly improved the management of lung carcinoma. However, the treatment for old patients can be more complex than that for young individuals.

Results

To investigate the benefits of genetic detection for older patients with lung carcinoma, we explored the genomic profiling of 258 patients with more than 55 years using a targeted next generation sequencing, and some of these patients were treated with targeted therapies based on the results of genomic detection. KRAS codon 61 mutations were found in 15.2% KRAS-mutated patients, which tend to be co-existing with other classical activating mutations other than codons 12/13. Acquired EGFR C797S mutations were identified in 2

SUBMITTER: Chen S 

PROVIDER: S-EPMC8760649 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature