Dynamic changes of CSF sPDGFRβ during ageing and AD progression and associations with CSF ATN biomarkers.

ABSTRACT:

Background

Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer's disease (AD). The role of pericyte in early stage of AD pathogenesis remains unclear.

Methods

We investigated the dynamic changes of soluble platelet-derived growth factor receptor β (sPDGFRβ) in cerebrospinal fluid (CSF), a marker of brain pericyte injury, in transition from normal ageing to early AD in a cognitively unimpaired population aged 20 to 90 years. Association between sPDGFRβ and ATN biomarkers were analyzed.

Results

In lifetime, CSF sPDGFRβ continually increased since age of 20 years, followed by the increases of phosphorylated tau-181 (P-tau181) and total tau (T-tau) at the age of 22.2 years and 31.7 years, respectively; CSF Aβ42 began to decl

SUBMITTER: Wang J 

PROVIDER: S-EPMC8760673 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature