Engineered adipose-derived stem cells with IGF-1-modified mRNA ameliorates osteoarthritis development.

ABSTRACT:

Background

Osteoarthritis (OA), a prevalent degenerative disease characterized by degradation of extracellular matrix (ECM), still lacks effective disease-modifying therapy. Mesenchymal stem cells (MSCs) transplantation has been regarded as the most promising approach for OA treatment while engrafting cells alone might not be adequate for effective regeneration. Genetic modification has been used to optimize MSC-based therapy; however, there are still significant limitations that prevent the clinical translation of this therapy including low efficacy and safety concerns. Recently, chemically modified mRNA (modRNA) represents a promising alternative for the gene-enhanced MSC therapy. In this regard, we hypothesized that adipose derived stem cells (ADSCs) engineered with modRNA encod

SUBMITTER: Wu H 

PROVIDER: S-EPMC8760691 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature