Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover.

ABSTRACT:

Background

Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However, prostate cancer cells inevitably adapt, resulting in disease relapse with incurable castrate-resistant prostate cancer. Androgen deprivation therapy has many side effects, including hypercholesterolemia, and more aggressive and castrate-resistant prostate cancers typically feature cellular accumulation of cholesterol stored in the form of cholesteryl esters. As cholesterol is a key substrate for de novo steroidogenesis in prostate cells, this study hypothesized that castrate-resistant/advanced prostate cancer cell growth is influenced by the availability of extracellular, low-density lipoprotein (LDL)-derived, cholester

SUBMITTER: Raftopulos NL 

PROVIDER: S-EPMC8760736 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature