Impact of Helicobacter pylori infection on fluid duodenal microbial community structure and microbial metabolic pathways.

ABSTRACT:

Background

The bioactivities of commensal duodenal microbiota greatly influence the biofunction of hosts. We investigated the role of Helicobacter pylori infection in extra-gastroduodenal diseases by determining the impact of H. pylori infection on the duodenal microbiota. We sequenced 16 S rRNA genes in samples aspirated from the descending duodenum of 47 (male, 20; female, 27) individuals who were screened for gastric cancer. Samples were analysed using 16 S rRNA gene amplicon sequencing, and the LEFSe and Kyoto Encyclopaedia of Genes and Genomes methods were used to determine whether the duodenal microflora and microbial biofunctions were affected using H. pylori infection.

Results

Thirteen and 34 participants tested positive and negative for H. pylori, respectively. We i

SUBMITTER: Maeda T 

PROVIDER: S-EPMC8760755 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature