Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents.

ABSTRACT:

Background

The role of dietary branched chain amino acids (BCAAs) and their effect on metabolic health is complex. How dietary BCAA levels and their interaction with background nutrition affect health is unclear. Here, we used meta-analysis and meta-regression, together with the nutritional modelling, to analyse the results of rodent studies that increased the level of dietary BCAAs and measured circulating levels, outcomes related to metabolic health, body mass and food intake.

Results

Across all studies, increasing dietary BCAAs resulted in increased levels of circulating BCAAs. These effects, however, were heavily moderated by background dietary levels whereby on high BCAA diets, further increases were not reflected in the blood. Impaired glucose tolerance was associated

SUBMITTER: Solon-Biet SM 

PROVIDER: S-EPMC8760763 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature